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Mavacamten Fails to Meet Primary Endpoints in Non-obstructive Hypertrophic Cardiomyopathy
Added: 7 months ago Source:  Radcliffe Cardiology
The ODYSSEY-HCM trial, evaluating the cardiac myosin inhibitor mavacamten in patients with symptomatic non-obstructive hypertrophic cardiomyopathy (HCM), did not meet its dual primary endpoints for improving functional capacity or patient-reported symptoms.¹ The findings were presented at the European Society of Cardiology (ESC) Congress 2025 and simultaneously published in the New England… View more

Guidelines & Statements

Heart Failure
Clinical Clues in Cardiovascular Disease
Author(s): Eva Gerdts , Faizel Osman , Yassir Javaid Added: 7 months ago
Esta serie de seis entrevistas, grabada en torno al ESC 2025, reúne a destacados expertos para compartir estrategias que favorezcan una detección más temprana y precisa de las enfermedades cardiovasculares. Las conversaciones destacan cómo los síntomas atípicos o sutiles de ictus e insuficiencia cardiaca pueden retrasar el diagnóstico, y por qué la vigilancia en la práctica clínica habitual es… View more

Imaging & Diagnostics

Prevention & Chronic Conditions
Clinical Clues in Cardiovascular Disease
Author(s): Eva Gerdts , Faizel Osman , Yassir Javaid Added: 7 months ago
Questa serie di sei interviste, registrata in occasione dell’ESC 2025, riunisce esperti di primo piano per condividere strategie volte a una diagnosi più precoce e accurata delle malattie cardiovascolari. Le discussioni mettono in evidenza come sintomi atipici o lievi di ictus e scompenso cardiaco possano ritardare la diagnosi, e perché la vigilanza nella pratica clinica quotidiana sia… View more

Imaging & Diagnostics

Prevention & Chronic Conditions
Demetri Yannopoulos
Research Area(s) / Expertise: Job title: Professor of Medicine
Personal History Born in London, UK, Dr Demetri Yannopoulos is one of the world’s leading researchers and advocates for the improvement of cardiac arrest care among cardiologists worldwide.4 In addition to being a Cardiologist, he is a Professor of Medicine, Research Director and Director of the Resuscitation Medicine Faculty at the University of Minnesota.1 Academic History In… View more
Steven E. Nissen
Research Area(s) / Expertise: Job title: Cardiologist
Dr Steven E. Nissen, an esteemed American cardiologist, researcher, and patient advocate, has left an indelible mark in the field of cardiology. Formerly the chairman of cardiovascular medicine at the renowned Cleveland Clinic in Ohio, Dr Nissen brings a wealth of experience and expertise to his roles.Joining the Cleveland Clinic in 1992, Dr. Nissen held key positions, including Vice-Chairman of… View more
Research Area(s) / Expertise: Job title: Professor of Medicine
Dr Martin B. Leon is a prominent figure in the field of interventional cardiovascular medicine, contributing significantly to the industry. Currently serving as the Professor of Medicine at Columbia University Irving Medical Center, he has held key roles such as the Director of the Columbia Interventional Cardiovascular Care and, until July 2023, Director of the Cardiovascular Data Science Center… View more
Marcelo F Di Carli
Research Area(s) / Expertise: Job title: Director, CV Imaging
Personal History Dr Marcelo Fernando DiCarli is the Executive Director of Cardiovascular Imaging program and Chief of the Division of Nuclear Medicine and Molecular Imaging, Department of Radiology at Brigham and Women’s Hospital. He is also the Seltzer Family Professor of Radiology and Medicine at Harvard Medical School.2 Academic History He got his M.D. from University of Buenos… View more
Andrew JS Coats
Research Area(s) / Expertise: Job title: Professor of Cardiology and Scientific Director
Professor Andrew Coats was born in Melbourne, Australia. He studied at St Catherine’s College, Oxford, where he earned a B.A. in Physiological Sciences with First-Class Honours, and then completed his medical degree (M.B. B.Chir.) at Clare College, Cambridge. He later obtained higher doctorates (D.M. and D.Sc.) in recognition of his substantial contributions to cardiovascular medicine, and he… View more
Vivek Reddy
Research Area(s) / Expertise: Job title: Director of Cardiac Arrhythmia Services
Dr. Vivek Y. Reddy is a renowned cardiac electrophysiologist based in New York, currently serving as Director of Cardiac Arrhythmia Services for The Mount Sinai Hospital and Director of Electrophysiology for the Mount Sinai Health System. He holds the Leona M. and Harry B. Helmsley Charitable Trust Professorship of Medicine in Cardiac Electrophysiology at the Icahn School of Medicine at Mount… View more
HFpEF-ABA Score Outperforms NT-proBNP in Trial Enrichment
Added: 4 months ago Source:  Radcliffe Cardiology
A new post hoc analysis of the SUMMIT trial suggests the HFpEF-ABA score is a more effective and inclusive enrichment tool than natriuretic peptide (NP) levels for clinical trials in patients with obesity-related heart failure with preserved ejection fraction (HFpEF).¹ The findings indicate the score, which is based on age, body mass index (BMI), and history of atrial fibrillation (AF), can… View more

Imaging & Diagnostics

Cardiovascular Kidney Metabolic