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MAPLE-HCM: Aficamten Outperforms Beta-Blocker in Obstructive Hypertrophic Cardiomyopathy
Added: 9 months ago Source:  Radcliffe Cardiology
Two phase 3 trials presented at the European Society of Cardiology Congress 2025 have provided new insights into the role of myosin inhibitors for hypertrophic cardiomyopathy (HCM), with one trial demonstrating superiority over standard care in obstructive HCM and another failing to meet its primary endpoints in the non-obstructive form of the disease.¹˒²The MAPLE-HCM trial found that the cardiac… View more

Guidelines & Statements

Heart Failure
Perry Elliott
Research Area(s) / Expertise: Job title: Director of UCL Institute of Cardiovascular Science and Professor of Cardiovascular Medicine
Professor Perry Mark Elliott was born on December 7, 1963, in London.6 He is a Professor of Cardiovascular Medicine at University College London (UCL) and a Senior Investigator of the UK National Institute for Health Research (NIHR).He is Director of the UCL Centre for Heart Muscle Disease, Head of Clinical Research at the Institute of Cardiovascular Science UCL and a consultant cardiologist in… View more
Kenneth Ellenbogen
Research Area(s) / Expertise: Job title: Professor and Chair, Division of Cardiology
Personal HistoryProf Kenneth A. Ellenbogen is a full Professor of Medicine (Cardiology) and Director of Clinical Cardiac Electrophysiology and Pacing at the Virginia Commonwealth University School of Medicine.He is a native of New York and speaks both English and French.3, 4Academic HistoryProf Ellenbogen obtained his undergraduate degree from Princeton University in 1976, where he graduated… View more
Eugene Braunwald
Research Area(s) / Expertise:

Cardiomyopathies

Heart Failure

 Job title: Distinguished Hersey Professor of Medicine, MACC
Personal History Dr Braunwald is an Austrian-born American cardiologist. He was born on August 15, 1929 to Jewish parents and moved to the United States in 1939.1, 3 “I had an idyllic childhood there with an excellent school and tutors in English and piano,” he says.6 He has a younger brother who became a haematologist.1 Music is one of Dr Braunwald’s passions. He is also a keen traveler:… View more
Acoramidis Efficacy in ATTR-CM Genotypes
Added: 7 months ago Source:  Radcliffe Cardiology
New analyses from the ATTRibute-CM trial show that the transthyretin (TTR) stabiliser acoramidis provides consistent clinical benefits in patients with both wild-type (ATTRwt-CM) and variant (ATTRv-CM) transthyretin amyloid cardiomyopathy.1 The findings include data from the main 30-month trial and its ongoing 42-month open-label extension (OLE).Acoramidis is an orally administered, small… View more

Inherited and Congenital Cardiac Conditions

Heart Failure
Added: 1 year ago
Explore the cardiovascular breakthroughs shaping AHA 2024!Join renowned experts Prof Nicolas Van Mieghem and Dr Joost Daemen (Thoraxcenter, Erasmus MC, Rotterdam, NL) as they preview the most impactful late-breaking studies poised to make waves at this year’s AHA Conference. Dive into their expert analysis and gain key insights into the studies that are set to drive the future of cardiovascular… View more

Intervention

Cardiovascular Kidney Metabolic
Pathophysiology, Mechanism, Diagnosis and Management of PAH
Author(s): Apoorva Gangavelli , Ronaldo C Fabiano , Mariam Riad , et al Added: 5 months ago

Prevention & Chronic Conditions
Overview of Genetic Risk Factors and Aetiologies
Author(s): Sarah Ming Li Tan , Shir Lynn Lim , Marcus EH Ong , et al Added: 10 months ago

Electrophysiology & Arrhythmia

Heart Failure
Added: 5 months ago Source:  Radcliffe Cardiology
A novel cardiac myosin agonist, danicamtiv, has shown favourable safety and efficacy signals in patients with dilated cardiomyopathy (DCM), particularly in those with specific genetic variants, according to results from a phase 2a open-label trial.¹ Precision therapies for DCM are currently lacking, despite its diverse clinical manifestations often linked to underlying genetic causes.²Danicamtiv… View more

Imaging & Diagnostics

Inherited and Congenital Cardiac Conditions
Takotsubo Syndrome in a Southeast Asian Population
Author(s): Samuel Soh Heng , Ignasius Jappar , Zee Pin Ding Added: 1 year ago

Imaging & Diagnostics

Heart Failure